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Copy Number Variants (CNVs) in Schizophrenia Study

CNVs are large stretches of DNA that have been either deleted or duplicated. Recently, certain CNVs have been identified in genome-wide association studies (GWAS) as being significantly associated with schizophrenia (SZ). The aim of this study is to discuver neurocognitive and neuroimaging variables associated with particular CNVs in or der to sub-type SCZ for further aetiological study. Using a wide range of clinical, neuropsychological and neuroimaging measures, we hope to characterize CNVs in SZ. Forty-seven SZ patients with SZ-associated CNVs (CNV+) have been compared with over five hundred SZ patients without CNVs (CNV-) on a wide range of clinical variables. Twenty-eight CNV+ patients have been cognitively assessed, as have forty-one CNV- patients. Recruitment for neuroimaging is ongoing, with over twenty SZ patients and ten healthy controls already scanned. Structural data will be acquired using structural magnetic resonance imaging (sMRI) and diffusion-tensor imaging (DTI). Functional data will be acquired using resting-state and functional magnetic resonance imaging (fMRI) with a theory of mind (ToM) task.