Does prenatal vitamin D deficiency lead to altered brain function in adulthood?

We have amassed considerable data to indicate that prenatal vitamin D deficiency may also change the way the brain functions in adulthood, in particular an area of the brain called the prefrontal cortex. An ongoing NHMRC Project Grant allows us to dissect the exact neural pathways altered by vitamin D deficiency during embryogenesis.

To date we have discovered a link between dopamine release in the prefrontal cortex and sensitivity to NMDA antagonists. This work may help unravel crucial neural pathways in schizophrenia.