Developmental Vitamin D deficiency induces impairments in Dopamine signalling; What are the mechanisms behind this?

Dysfunction in dopamine signaling remains the cornerstone of all therapeutic approaches to treating schizophrenia. We have discovered that maternal vitamin D deficiency alters the way dopamine neurons develop. This exciting finding may bring together two of the most important hypotheses in schizophrenia, namely the “dopamine hypothesis” and the “neurodevelopmental hypothesis.”

We continue to explore this risk in the DVD-deficiency model but are now broadening our approach to incorporate other developmental animal models for this disease such as maternal infection. It is hoped such an approach will lead to uncovering convergent pathways in many disparate risk factors for this disease.